Spondyloarthropathy is a term for joint disease; in fact any joint disease can be termed as spondyloarthropathy. If any joint related disease occurs with inflammation is known as spondyloarthritis. In Spondyloarthritis, Ankylosing spondylitis is a type. Ankylosing spondylitis rheumatoid arthritis is a chronic inflammatory disease. It is also an autoimmune disease, which mainly affects spine, sacroiliac, and pelvis joints. Ankylosing spondylitis can fuse and restrict the vertebrae and lead to cramp posture.
Ankylosing spondylitis typically affects people between the age group of 20 to 40, especially young males. Sometimes patients may suffer from this disease in a very young age, like 18-19. In this early age symptoms like pain in the large joints is most likely to happen. In many prepubertal cases swelling along with pain might trigger in the ankles and feet. According to the general observations males get affected more than females in cases of A S.
A S can be subjected as a hereditary disease. It is pretty hard to relate the disease in the first place as symptoms are common to many other diseases and it can be misleading. Primary symptoms of this disease are; stiffness along with pain in the central vertebral column, patients also complain about the lower back pain sometimes in the buttock region. In many cases it is seen that pain can penetrate up to sacroiliac joint.
Human Leukocyte Antigen or H L A – B 27 gene has been identified as the main responsible gene for igniting the ankylosing spondylitis rheumatoid arthritis. Patients suffering from A S show signs of iritis and uveitis. Some may suffer from multiple ocular problems such as; redness in eyes, photophobia, partial loss of vision etc. A S have serostatus negative, that means R F factor is negative. Seronegative spondyloarthropathies is a pool of diseases which involve the axial skeleton and ankylosing spondylitis rheumatoid arthritis is one among the many diseases which falls under this cluster. In A S disease it mainly involves the axial skeleton.
As such no medicinal cure is available in this point of time for ankylosing spondylitis rheumatoid arthritis. Some useful drugs are definitely there to reduce complications and trouble caused by pain and inflammation. It is very time consuming to gauge the actual on-set of the disease, even with x-ray. It is quite difficult to say whether the person is suffering from A S or not. Magnetic resonance imaging or M R I can be a potent tool for the diagnosis of A S but the reliability of these tests are not very clear. Among all the diagnostic tools, genetic marker blood tests and Schober’s test are among the most reliable.
Physicians prefer treating this disease first with N S A I D (non steroidal anti inflammatory drug) like; ibuprofen, naproxen, diclofenac, Cox 2 inhibitors etc. D M A R D (disease modifying anti rheumatoid drug) is also been among the top prescribed medicine, T N F alpha blockers like; golimumab, adalimumab, etanercept are used to suppress some auto antigen. But with all these medicine risks of side effects is huge and largely experienced in most cases, as a result patients suffering from ankylosing spondylitis rheumatoid arthritis are preferring therapies or even switching to alternative medicines.