Rheumatoid Arthritis is a chronic inflammatory disease and extra-articular manifestation is common in patients with Rheumatoid Arthritis. The occurrence of these articular manifestations is reported to have 7% to 13%, excluding the studies of cardiovascular disease. Extra-articular manifestations of this disease are associated with rate of incidence and increased in mortality rate. Some studies have suggested that a patient of Rheumatoid Arthritis with articular manifestations, have less risk of mortality rate, as compared to the generals. These articular manifestations are somehow related with increased disease activity, which generally causes increase in level of inflammation like high levels of C- reactive protein (CRP) and rheumatoid Factor (RF). It suggests that early treatment of Rheumatoid Arthritis, with some effective exercise and therapies brings lower the risk and severity of this manifestations which are associated with these disease.
Rheumatoid arthritis is generally, a chronic, and disabling articular disease. If most patients try to do well (because of efficient treatment) they may have only extra-articular rheumatoid arthritis. The clinical manifestations of this rheumatoid arthritis are varied, ranging from general and benign manifestations such as rheumatoid nodules to severe conditions such as Systemic vasculitis or Felty’s syndrome. The incidence of systemic rheumatoid arthritis seems cumulative as the disease progresses over the course of time, and the severity of individual’s lesions, when fully developed and could be of major importance and even increases the mortality rate of the patient.
Suggested researchers or predictors of Extra Articular Manifestation of Rheumatoid Arthritis, include some factors such as male sex and some genes, auto-anti-bodies such as Rheumatoid Factor (RF) and Anti-Nuclear Antibodies (ANA), and other factors such as hazardous working conditions like working in silicon mineral and coal dust, consumption of alcohol, nicotine, and smoking. The strength of this assemblage is diverse depending on the true explanation of ERA used, and on the method of selection of a patient. We are very much grateful to some people like Philip Ell man, for their inception work on the subject and also for their attitude towards the disease.
Extra Articular Manifestation is nothing but appearance of some tendonitis (inflammation of tendons). This may occur in several joints like knees, elbows, feet, wrist, etc. This is the only feature that differentiates from other types of arthritis. It is known to have effect the whole body of a patient. This is a very vast subject and it is not possible for a single person to have expertise in it. A disease affecting some 3 % or more of the Population at sometime in their lives, lasting usually many years, and often the rest of the patients’ lives, merits considerable study. Recently some genuine studies of natural history had been made which shows that some intimacy of articular and non- articular manifestation is required. So its treatment is very important especially in its early stage as potential treatment can even cure this fatal disease, but before that its diagnosis is very crucial.