Causes of Rheumatoid Arthritis
The actual cause of rheumatoid arthritis is not yet known, but some infectious agents such as viruses, fungi, and bacteria have proven to have the actual cause. It is also believed that a patient may have inherited rheumatoid arthritis genetically. There are certain genes that increase the risk of Rheumatoid arthritis. Some other factors that activate the immune system in some patients are infections and some environmental factor. In this chronic autoimmune disease the immune system then attacks the body’s own tissues, which leads to inflammation to the joints and sometimes in various organs of the body, such as the lungs, kidneys, or eyes. Environmental factors like smoking tobacco, exposure to silica mineral, and chronic periodontal disease, causes a high risk of developing Rheumatoid Arthritis.
Rheumatoid Arthritis’s actual onset is not yet known, but some immune cells, also called cellular immunity may be ignited and some chemical bearer like cytokines, such as tumor necrosis factor (TNF), interleukin and interleukin, are observed in the areas of inflammation.
Some signs and symptoms
The symptoms of rheumatoid arthritis come and go, depending on the degree of tissue inflammation. The disease is active when there is any inflammation in the body tissue and vice-versa. Some remissions can be seen to have occurred spontaneously and may last for weeks, months, or years. During this phase people generally feel some sort of comfort but it may become active again and symptoms too, may return, which is called a flare. The course of rheumatoid arthritis varies in different individuals, and time of flares and remissions are also different.
Fatigue, lack of appetite, low-grade fever, loss of energy, stiffness, and muscle and joint aches are some symptoms, when the disease is active. The most notable thing in the morning is the inactivity of the joint muscles particularly for one hour. During flares, joints certainly get red, swollen, painful, and tender. This occurs because synovial joints swells, resulting in excessive joint fluid.
This generally includes inflammation of joints in a chorological pattern by having both sides of the body affected. The small joints of the hands and wrists are primarily involved. These symptoms forbid tasks of daily chores. The small joints of the feet are also affected, which may sometimes lead to painful walking, especially in the morning. When there is only one joint involved, the arthritis can imitate the joint inflammation and can cause other forms of arthritis like gout or joint infection. This inflammation can cause some damage to different body tissues, including the cartilages and bones, and can conclude to loss of cartilages, erosion of bones, and weakness of the muscles as well, resulting in joint deformity, destruction, and limitation of function. Rheumatoid arthritis can even affect the joints which are responsible for the tightening of our vocal cords to change the tone of our voice but in rare cases. Several symptoms like limping, irritability, crying, and poor appetite can be seen in children with Rheumatoid Arthritis.s