Actual cause for the rheumatoid arthritis is still in speculative nature. Scientists and researchers are trying to join different factors for the actual pathogenesis for this disease. Is rheumatoid arthritis hereditary? This question cannot be replied in a single answer with authority. Different factors of the disease are already the subject for researchers; they are scrutinizing all the possibilities to come to a conclusion. Till date all they are saying is, cause of rheumatoid arthritis can arise from many noticeable factors. As no curative conclusion is available this point of time, parents can get mentally imbalanced, they needn’t to blame neither them nor their forefathers. But parents can be best assured that there is no certain proof of rheumatoid arthritis being a hereditary disease. Yes, some gene can play a major role to trigger R A.
As an autoimmune disease, the body’s own immunity system finds their own system as a probable pathogen or infectious agent, and killing them. This whole process that leads to rheumatoid arthritis is known as auto-immune disorder. Auto-immune disorder is a genetical factor and PTPN22 (protein tyrosine phosphate, non-receptor type-22) gene is the main contributory gene for the rheumatoid arthritis.
Cytokine is a small cell signaling protein molecules, among the cytokines there are divisions that are pro inflammatory and anti inflammatory. Pro inflammatory cytokines are the regulatory cytokines which acts to make the disease aggravate, and the anti inflammatory cytokine are the agent to stabilize the inflammations. Interleukin-1 (IL1) and TNF (tumor necrosis factors) are the two most common pro inflammatory cytokine. HLA-DR is surface receptors of cells, and in investigations shows the HLA-DR can be a major gene that can be directly addressed to rheumatoid disease or arthritis. HLA (human leukocyte antigen), and of the subgroup DR, isoform DR4 is getting all attention to be directly associated with the rheumatoid arthritis.
All these studies in the field of genetics paint out the actual facts, that gene play a vital part in the rheumatoid arthritis disease. And if somebody is an expectant mother and she is suffering from R A. It is quite natural to have concerned for her child. But these studies show certain diseased gene can be the cause for rheumatoid arthritis, but not with surety that this disease is going to pass on to her child. Expectant mother can take a chill pill, after this scientific assurance.
There is a cliché, “prevention is always better than cure”. And R A is not certainly a disease which can be cured completely, nor does it have a great deal of option to be prevented. But if traced in early stage it can be very beneficial. As parents or like common human one must have proper knowledge regarding rheumatoid arthritis reading about the disease, and consulting the physician might help to gain some information about it. Is rheumatoid arthritis hereditary? Answer for this question is too early to say in a conclusive fashion.