Rheumatoid arthritis is a form of chronic inflammatory arthritis, it is an incurable disease caused by autoimmune disorder. The complete reasons behind this auto immune disease are not known comprehensively. Patients having rheumatoid arthritis develops auto antibody, where body’s own immune system gets misguided and attacks its own healthy tissues like the synovial lining, a fine layer of membrane in the joints that holds the synovial fluid. Due to pannus formation in and around the articular cartilage, joint gets quickly eroded because of the friction; hence resulting inflammation along with the severe pain are the common symptoms. R A is a systemic disease which means not only it affects joints, but its effect can be felt throughout the human body system. Most common symptoms of R A is fatigue, rheumatoid arthritis and fatigue goes parallelly, other than this primary symptoms malaise, appetite loss and muscle ache are some of the primary symptoms.
Symptom of fatigue is quite physically and mentally draining, as if a tremendous exertion is felt all day long without any remarkable physical activity. It is a sign of weariness, taking rest cannot completely solve the problem. The most common clinical symptoms in rheumatoid arthritis is fatigue, more than 92% of the patients suffer from this symptom. It is the most difficult symptom faced by an R A patient after the pain, living with fatigue can take quite a toll out of a patient.
Actual reason for the symptoms of fatigue may be caused due to inflammation, side effects of medication, excessive amount of physical activities, stress and depression related issue or the combination of both. Insomnia or sleeplessness and deficiency of nutrition in the body, and avoiding of regular physical work outs may contribute to the factor. Depression and stress might grasp a patient because of the continuous feeling of exertion. Physical exertion can decrease the body’s immune system immensely, resulting to more susceptible to illness.
There are more contributing factors for the symptom of fatigue. Most contributory of all is the cytokines.A cell can communicate among each other, small protein molecules with signaling capability are known as cytokines. Cytokines are divided into two types pro and anti inflammatory. Pro inflammatory cytokines are the ones who are responsible to make disease aggravate. Specific chemicals which cause the fatigue are directly related to flu and dizziness. Reason behind suspecting cytokines are many, but among the most noted cause is; when T N F alpha blocker drug is consumed by a patient, symptoms of fatigue gets minimized. As T N F alpha inhibitor suppress the cytokines like T NF alpha and I L 1.
Rheumatoid arthritis and fatigue is certainly co-related with each other, though fatigue can’t be blamed for the rheumatoid arthritis because R A can’t be caused only because of exertion. However fatigue can deteriorate the disease by some margin. Rest is very crucial to fight R A, but it has no guarantee that it will prevent the fatigue. But setting a daily routine, which will include physical activity and balancing it equally with rest, can be the smartest of choices to conserve energy and strength.