Rheumatoid arthritis can be termed as a systemic inflammatory disorder and it is a chronic disease. R A causes inflammation in and around the synovial joint which is known as diarthrosis. Inflammation is caused due to production of excessive synovial fluids onto the fibrous tissues. It manipulates several organs by producing some inflammation in the lungs, by forming nodules and membranes around heart, lungs, liver, kidney, etc. Generally rheumatoid arthritis stages can be categorized under the main four points. But some researchers prefer to divide it into five points. All these stages reflect the exact condition of the patient during the tenure of the disease. The status can be classified into four stages; basically it is about the unrestrained inflammation and the way it deteriorates in the ongoing process of rheumatoid arthritis stages.
RHEUMATOID ARTHRITIS STAGE 1
People suffering from R A develop the process of inflammation in the synovial membrane known as synovitis. Increase of pro inflammatory cytokines like, Interleukin-1 (IL 1) and Tumor necrosis factor alpha (T N F alpha) increase the process of inflammation quite rapidly. Due to unnatural secretion of chemical in the body, effects like redness around the joint, swelling, fatigue, warmth and joint pain can be witnessed.
RHEUMATOID ARTHRITIS STAGE 2
Due to the certain increase in synovial fluid content, stiffness along with lack of freeness in motion capability of the joints happen. A common term called joint effusion can be witnessed in many cases. Increase in uric acid level in the blood is mainly responsible for this symptom. Among all the rheumatoid arthritis stages, accumulation in joint pain, swelling, mobility loss, morning stiffness is inevitable.
RHEUMATOID ARTHRITIS STAGE 3
In this stage inflamed synovial membrane overlaps and raps around the cartilage present in the joint. Deterioration of the joint cartilage and may be even breakdown of it can eventually happen, this can particularly cause severe damage to the bones, as cartilage is responsible for the protection of the bone and joints. Pannus formation is key sign in this stage, in the interface between pannus and cartilage activated synovial fibroblasts and macrophages are resource of enzymes that degrade the cartilage matrix, these include matrix (M M Ps) mettaloproteinases thus activated cells and pannus are key instigators of cartilage destructions.
RHEUMATOID ARTHRITIS STAGE 4
Cartilage acts as a cushioning factor for the bones, excess damage to the cartilage can cause bone erosion, which causes serious pain around the joint. During this phase feeling of the symptom named crepitus is common. Crepitus is kind of a crackling or grating sound of the joints. People suffering from rheumatoid arthritis in their final stage, symptoms like decrease in joint inflammation can be seen but damage caused to the joints is absolutely irreversible. Deformation in shapes of the fingers and other joint deformation along with serious mobility loss are bound to happen. Physical endurance of a patient is restricted to a minimal condition. In this final stage mental condition of a patient is most affected. Helplessness because of the mobility restriction, jolt heavily on the patient’s mind.
With symptoms that relates to anyone, from any of these rheumatoid arthritis stages, one must not waste any time, and should seek doctor’s advice immediately.