What causes Rheumatoid Arthritis? This question regarding this disease might not have any conclusive medical remedy till now. This raised a thought of concern amongst the medical and researcher’s fraternity. More than 1% of total world’s population is affected with this chronic ailment. A simplified definition of this disease would be; A systemic inflammatory disorder which primarily affects the Synovial joints. Mainly leading to swelling, resulting stiffness & severe pain in joints.
Pathogenesis or resultant effects of this disease may be many; the conclusive causes are still in-convincing and incomplete in many a ways. Optimist believes in their destiny and still in pursuit of reply for a curative conclusion. There are many intricate researches leading to many diverse results for the root cause. From many, some notable evidences for the causes of Rheumatoid Arthritis are as follows:
TUMOUR NECROSIS FACTORS, TNF (ALPHA): It’s a small cell-signaling protein molecule, can be classified as proteins or glycoproteins, and also falls under cytokines group which can be a central factor for the cause of cell death (Apoptosis). This might be one of the factors for Rheumatoid Arthritis.
GENETICAL FACTORS (HEREDITARY): PTPN22 or Protein Tyrosine Phosphate, Non Receptor type 22 gene has been identified as a contributory factor with Auto-Immune Disorders. Mainly in Auto-Immune Disorders, body’s own immune system conflict with its own parts resembling as a pathogen or kind of a virus and targets its own cells resulting in co-lateral damage. Hereditary factors were found in many cases, studies shows that disease parental lineage contribute overall in major ways.
HORMONAL FACTORS: Studies shows, among the pregnant women’s or a mother of a new born child tend to have hormonal changes in them resulting Rheumatoid Arthritis. Intake of anabolic steroids, tendency mostly found in athletes & among many youths can also be a cause for Rheumatoid Arthritis.
ENVIORNMENTAL FACTORS: Lifestyle of different natures such as addiction, especially consumption of tobacco can have some effect. Un-restrained lifestyle, obesity which comes from excessive binging leads to RA. Pollution of different natures such as working around hazardous silica dust which causes disability of musculoskeletal system disorder may trigger this disease.
OTHER FACTORS: Disproportionate intake of contraceptive pills can trigger the process of Rheumatoid Arthritis. Some scientists have suggested that bacterial infection or in case of chronic viral attack can also create dent that may affect which causes Rheumatoid Arthritis.
Whatever may be the causes, it is very much understood that Rheumatoid Arthritis can’t happen because of only one cause. Its causes are really multi-triggered by different things that escalate the disease. What causes Rheumatoid Arthritis is certainly a speculation, jotting down different points and joining them together. Scientists and doctors are trying their level best to find out the main reason that mainly triggers this disease. Like every optimist they are on their way heading straight into the direction where they can find the ray of light for all of those who are suffering from this incurable disease. If they are relentlessly trying what they can do best, so why we can’t find a way out by leading a healthy and a restrained life, so that we can build up our immunity and give it a realistic chance to mange this disease successfully.